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Quodixor

What other drugs will affect Quodixor

Многие годы безуспешно боретесь с БОЛЯМИ в СУСТАВАХ?

Глава Института: «Вы будете поражены, насколько просто можно вылечить суставы принимая каждый день средство за 147 рублей...

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Tell your doctor about all other medicines you use, especially aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as:

  • celecoxib (Celebrex);
  • diclofenac (Voltaren);
  • diflunisal (Dolobid);
  • ibuprofen (Motrin, Advil);
  • indomethacin (Indocin);
  • ketoprofen (Orudis)
  • ketorolac (Toradol);
  • naproxen (Aleve, Naprosyn); or
  • piroxicam (Feldene), and others.

This list is not complete and other drugs may interact with ibandronate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

НАШИ ЧИТАТЕЛИ РЕКОМЕНДУЮТ!

Для лечения суставов наши читатели успешно используют Артрейд. Видя, такую популярность этого средства мы решили предложить его и вашему вниманию.
Подробнее здесь…

Симптомы

На ранних стадиях остеопороз является бессимптомным или малосимптомным заболеванием, которое может маскироваться под другие болезни, например под остеохондроз позвоночника или артроз суставов.

Часто остеопороз впервые диагностируется уже при наличии перелома какой-либо кости. При этом переломы могут возникать при малейшей травме или поднятии тяжести. Кости истончаются без каких-либо заметных проявлений, и человек не подозревает о наличии у него остеопороза, пока случайно не упадет и не сломает руку или ногу.

И всё же существует несколько признаков, по которым можно заподозрить наличие остеопороза: изменение осанки, боли в костях и суставах при изменениях погоды, хрупкость ногтей, разрушение зубов.

Quodixor

Первыми «звоночками» остеопороза могут стать боли в пояснице и грудном отделе позвоночника при длительной статической нагрузке (например, при сидячей работе), судороги ног по ночам, формирование старческой сутулости, уменьшение роста (уменьшается высота позвонков), явления пародонтоза, затруднение движений.

Остеопороз может проявляться:

  • болями в спине ноющего характера (боли, как правило, возникают при длительном пребывании (более получаса) в одной позе в положении стоя или сидя);
  • симптомами остеопороза может быть уменьшение роста;
  • появлением кифоза — возрастной сутулости (кифоз может достигать крайней степени, когда происходит затруднение дыхания);
  • судороги мышц ног;
  • усталость, слабость, повышенная утомляемость — это тоже косвенные симптомы остеопороза;
  • повышенная хрупкость ногтей;
  • пародонтоз;
  • ранее поседение волос.

Select the most affordable brand or generic drug

Generic drug is the basic drug with an active substance in it, and the name of the generic drug is same as active substance most of the times. Like Acetaminophen/Paracetemol is Generic name and it has different brand names like Tylenol, Acimol, Crocin, Calpol etc. All these Brand names contain the same Paracetemol, but the medications are manufactured by different companies, so the different brand names. Generic drug is always cheaper and affordable, and it can be replaced in place of brand name drug prescribed by the healthcare practitioner. The Generic medicine has same properties as branded medicine in terms of uses, indications, doses, side effects, so no need to worry on that. Just select the most affordable generic or branded medicine.

Strength Quantity Price, USD Country
Acide Ibandronique Teva
Acido Ibandronico Cinfa
Acido Ibandronico Normon
Acido Ibandronico Qualigen
Bon-Fild
Bonames
Bonat
Bondenza
Bondrova
Bonessa
Boniva
150 mg 2 $124.49 Canada, Mauritius, Singapore, Turkey, UK, USA
150 mg 3 $109.00 Australia, Canada, NZ, Singapore, Turkey
150 mg 3 $127.80 Australia, Canada, India, NZ, Singapore, Turkey, UK, USA
150 mg 3 $128.00 Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
150 mg 3 $135.00 Australia, Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
150 mg 6 $197.00 Canada, Mauritius, NZ, Singapore, Turkey, UK, USA
Bonjenic
Bonosta
Boost Diabetic Chocolate
mg 4 $56.00 Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK, USA
mg 4 $56.00 Australia, Canada, India, Mauritius, NZ, Singapore, Turkey, UK
Dongkwang Ibandronate
Elasterin Max
Fijacal
Ibandrix
Ibandro
Ibandronat Apotex
Ibandronat PharmaS
Ibandronat Polpharma
Ibandronat-Mepha
Ibandronate Mithra
Ibandronate Sodium Apotex
Ibandronate Sodium Orchid Healthcare
Ibandronato Richet
Ibandronian Actavis
Ibandronic Acid Actavis
Ibandronic Acid Mylan
Ibandronic Acid Noridem
Ibandronic Acid Sandoz
Ibandroninezuur CF
Ibandroninezuur Genthon
Ibandroninezuur SUN
Ibandroninezuur-CT
Ibandrons?ure HEXAL
Ibandronsyre Sandoz
Ibandronsäure — 1 A Pharma
Ibandronsäure Q-Pharm
Ibandronsäure SUN
Ibanfos
Ibone
Ibostofar
Ibrac
Indrofar
Ipexal
Jia Nuo Shun
Mesel
Nucodran
Osteocalcit
Posclim
Recaxin
Recaxin Duo
Resormes
Sempriban
Vivanat Rompharm
Ácido Ibandrónico Accord
Ácido Ibandrónico Labesfal
Ácido Ibandrónico Leugim
Ácido Ibandrónico Synthon
Ácido Ibandrónico ToLife

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Read drug prescription

It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Quodixor before taking it.

What is Quodixor

Quodixor

Important safety information:

  • Quodixor may cause dizziness. This effect may be worse if you use it with alcohol or certain medicines. Use Quodixor with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Follow the diet and exercise program given to you by your health care provider. Talk to your doctor about whether you should take a calcium and vitamin D supplement while you use Quodixor.
  • Talk to your doctor about the use of weight-bearing exercises to help prevent weak bones.
  • Certain fractures of the thigh bone have been reported in patients using bisphosphonates. It is not known if bisphosphonates contributed to the fractures. Contact your doctor right away if you experience hip, thigh, or groin pain. Discuss any questions or concerns with your doctor.
  • Quodixor may cause jawbone problems in some patients. Your risk may be greater the longer you take Quodixor or if you have cancer, poor dental hygiene, or certain other conditions (eg, anemia, blood clotting problems, infection, dental problems). Your risk may also be greater if you have certain dental procedures or you are using certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before starting Quodixor. Ask your doctor any questions you may have about dental treatment while you use Quodixor.
  • Proper dental care is important while you are using Quodixor. Brush and floss your teeth and visit the dentist regularly.
  • Certain dental procedures should be avoided if possible while you are using Quodixor. Tell your doctor or dentist that you use Quodixor before you receive any medical or dental care, emergency care, or surgery.
  • Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor.
  • Quodixor may interfere with certain lab or diagnostic tests that use a bone-imaging agent. Be sure your doctor and lab personnel know that you are using Quodixor.
  • Lab tests, including bone density, kidney function, and blood calcium levels, may be performed while you use Quodixor. These tests may be used to monitor your condition or check for side effects. Your doctor may also want to evaluate you periodically while you use Quodixor to assess the need to continue its treatment. Be sure to keep all doctor and lab appointments.
  • Quodixor should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Quodixor while you are pregnant. It is not known if Quodixor is found in breast milk. If you are or will be breast-feeding while you use Quodixor, check with your doctor. Discuss any possible risks to your baby.

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Quodixor side effects

Diarrhea; dizziness; headache; heartburn; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms (eg, mild fever, chills, tiredness, weakness, joint or muscle aches); nausea; pain, swelling, or redness at the injection site; stomach pain or upset.
Severe allergic reactions (rash; hives; itching; difficulty breathing; fainting; fast heartbeat; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; unusual sweating; wheezing); change in the amount of urine produced; eye pain; mouth sores; painful or difficult urination; severe bone, joint, or muscle pain (especially in the hip, groin, or thigh); severe or persistent dizziness or headache; severe or persistent heartburn or stomach pain; swelling or pain in your jaw; symptoms of low blood calcium (eg, spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes, or around your mouth); vision changes.

Active ingredients: Ibandronic Acid

Quodixor indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Treatment of Postmenopausal Osteoporosis

Quodixor Injection is indicated for the treatment of osteoporosis in postmenopausal women. In postmenopausal women with osteoporosis, Quodixor increases bone mineral density (BMD) and reduces the incidence of vertebral fractures.

Important Limitations of Use

The safety and effectiveness of Quodixor for the treatment of osteoporosis are based on clinical data of one year duration. The optimal duration of use has not been determined. All patients on bisphosphonate therapy should have the need for continued therapy re-evaluated on a periodic basis. Patients at low-risk for fracture should be considered for drug discontinuation after 3 to 5 years of use. Patients who discontinue therapy should have their risk for fracture re-evaluated periodically.

How should I use Quodixor

Use Quodixor exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Quodixor tablets are taken either once each day or once each month. The intravenous solution is given as an injection into one of your veins once every 3 months. A healthcare provider will give you this injection. The tablets can be taken at home.

Take the Quodixor tablet first thing in the morning, at least 1 hour (60 minutes) before you eat or drink anything or take any other medicine. If you take a tablet only once a month, take it on the same day each month and always first thing in the morning.

Take each Quodixor tablet with a full glass (6 to 8 ounces) of water. Use only plain water (not mineral water) when taking a tablet.

Do not crush, cut, chew, or suck the Quodixor tablet. Swallow the tablet whole.

For at least 1 full hour after taking an Quodixor tablet:

To be sure Quodixor is helping your condition, your bone mineral density will need to be tested often. You may not need to take this medicine for longer than 3 to 5 years.

If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Quodixor. You may need to stop using the medicine for a short time.

Quodixor is only part of a complete program of treatment that may also include diet changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat.

Quodixor interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Quodixor, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Drug-Food Interactions: Products containing calcium and other multivalent cations (eg, aluminium, magnesium, iron), including milk and food, are likely to interfere with absorption of Quodixor which is consistent with findings in animal studies. Therefore, with such products, including food, intake must be delayed for 60 min following oral administration.

Drug-Drug Interactions: It is likely that calcium supplements, antacids and some oral medications containing multivalent cations (eg, aluminium, magnesium, iron) are likely to interfere with the absorption of Quodixor. Therefore, patients must wait 60 min after taking Quodixor before taking other oral medications.

Pharmacokinetic interaction studies in postmenopausal women have demonstrated the absence of any interaction potential with tamoxifen or hormone replacement therapy (estrogen). No interaction was observed when co-administered with melphalan/prednisolone in patients with multiple myeloma.

In healthy male volunteers and postmenopausal women, IV ranitidine caused an increase in Quodixor bioavailability of about 20%, probably as a result of reduced gastric acidity. However, since this increase is within the normal range of the bioavailability of Quodixor, no dosage adjustment is required when Quodixor is administered with H2-antagonists or other drugs which increase gastric pH.

In relation to disposition, no drug interactions of clinical significance are considered likely, since Quodixor does not inhibit the major human hepatic P450 isoenzymes and has been shown not to induce the hepatic cytochrome P450 system in rats. Furthermore, plasma protein binding is low at therapeutic concentrations and Quodixor is therefore unlikely to displace other drugs.

Quodixor is eliminated by renal excretion only and does not undergo any biotransformation. The secretory pathway appears not to include known acidic or basic transport systems involved in the excretion of other drugs.

In a 1-year study in postmenopausal women with osteoporosis (BM16549), the incidence of upper gastrointestinal events in patients concomitantly taking aspirin or NSAIDs was similar in patients taking Quodixor 2.5 mg daily or 150 mg once monthly.

Of over 1500 patients enrolled in study BM16549 comparing monthly with daily dosing regimens of Quodixor, 14% of patients used histamine (H2)-blockers or proton-pump inhibitors. Among these patients, the incidence of upper gastrointestinal events in the patients treated with Quodixor 150 mg once monthly was similar to that in patients treated with Quodixor 2.5 mg daily.

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Quodixor contraindications

See also:What is the most important information I should know about Quodixor?

Hypersensitivity to Quodixor or to any of the excipients of Quodixor.

Patients with uncorrected hypocalcemia. As with all bisphosphonates indicated in the treatment of osteoporosis, preexisting hypocalcemia needs to be corrected before initiating therapy with Quodixor. As with several bisphosphonates, Quodixor is contraindicated in patients with abnormalities of the esophagus which delay esophageal emptying eg, stricture or achalasia.

Patients who are unable to stand or sit upright for at least 60 min.

Use in pregnancy: Quodixor should not be used during pregnancy.

There was no evidence for a direct fetal toxic or teratogenic effect of Quodixor in daily orally treated rats and rabbits and there were no adverse effects on the development in F1 offspring in rats. Adverse effects of Quodixor in reproductive toxicity studies in the rat were those observed with bisphosphonates as a class. They include a decreased number of implantation sites, interference with natural delivery (dystocia), and an increase in visceral variations (renal pelvis ureter syndrome). Specific studies for the monthly regimen have not been performed.

НАШИ ЧИТАТЕЛИ РЕКОМЕНДУЮТ!

Для лечения суставов наши читатели успешно используют Артрейд. Видя, такую популярность этого средства мы решили предложить его и вашему вниманию.
Подробнее здесь…

There is no clinical experience with Quodixor in pregnant women.

Use in lactation: Quodixor should not be used during lactation.

In lactating rats treated with 0.08 mg/kg/day IV Quodixor, the highest concentration of Quodixor in breast milk was 8.1 ng/mL and was seen in the first 2 hrs after IV administration. After 24 hrs, the concentration in milk and plasma was similar and corresponded to about 5% of the concentration measured after 2 hrs.

It is not known whether Quodixor is excreted in human milk.

Active ingredient matches for Quodixor:

Ibandronic Acid in Bulgaria, Netherlands, Poland, Portugal.

List of Quodixor substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer) Price, USD
Osbonelle (Bulgaria, Hungary, Malta, Netherlands, Poland)
Oseban (Colombia, Guatemala)
Oseum (Argentina)
Injectable; Injection; Calcitonin, Salmon 100 IU / ml (Grossman)
Spray; Nasal; Calcitonin, Salmon 200 IU / dose (Grossman)
Osmac (South Korea)
Ossica (Bulgaria, Estonia)
Ostea (Croatia (Hrvatska))
Osteocalcit (Colombia)
Osteolong (Colombia)
Osteosyl (Peru)
Osteoviva (Austria)
OSTIUM K2
Ostone (Poland)
Phacebonate (Czech Republic, Hungary, Netherlands)
Posclim (Argentina)
Ratiban (Portugal)
Recaxin (Chile)
Tablet; Oral; Ibandronate Sodium Monohydrate 150 mg
Recaxin Duo (Chile)
Resormes (Peru)
Ribobandron (Germany, Netherlands)
Sedropor (Greece)
Sempriban (Turkey)
Silidral Uno (Argentina)
Speconate (Greece)
Spesostoun (Greece)
Unomes (Colombia)
VEBALONE (India)
3 mg x 3 mL x 1’s (Croslands (Ranbaxy Laboratories Ltd) $ 31.75
150 mg x 1’s (Croslands (Ranbaxy Laboratories Ltd) $ 3.06
Vebalone 150 mg Tablet (Croslands (Ranbaxy Laboratories Ltd) $ 3.06
Vebalone 3mg x 3mL INJ / 3ml (Croslands (Ranbaxy Laboratories Ltd) $ 31.75
Vebalone 150mg FC-TAB / 1 (Croslands (Ranbaxy Laboratories Ltd) $ 3.35
VEBALONE 150MG TABLET 1 strip / 1 tablet each (Croslands (Ranbaxy Laboratories Ltd) $ 4.00
VEBALONE 3 MG INJECTION 1 vial / 3 ML injection each (Croslands (Ranbaxy Laboratories Ltd) $ 31.75
VEBALONE inj 3 mg x 3 mL x 3ml (Croslands (Ranbaxy Laboratories Ltd) $ 31.75
VEBALONE film-coated tab 150 mg x 1’s (Croslands (Ranbaxy Laboratories Ltd) $ 3.35
Vebalone 3mg x 3mL INJ / 3ml (Croslands (Ranbaxy Laboratories Ltd) $ 31.75
Vebalone 150mg FC-TAB / 1 (Croslands (Ranbaxy Laboratories Ltd) $ 3.35
Vebalone 150mg Tablet (Croslands (Ranbaxy Laboratories Ltd) $ 4.00
Vivanat Rompharm (Georgia)
Voliran (Greece)
Voliran 100mg Tablet SR (Intas Pharmaceuticals Ltd) $ 0.01
Ziveteno (Lithuania)

Профилактика заболевания

В первую очередь для профилактики заболевания в пищу употребляется кальций. Нехватка данного вещества плохо сказывается на организме. Помимо кальция, профилактика остеопороза заключается в обеспечении организма фосфором и магнием, а также витамином D. Весь этот комплекс помогает кальцию усваиваться.

QuodixorДля профилактики остеопороза нужно правильно питаться.

Нужные для костей элементы вы получите из таких продуктов питания:

  • кисломолочные продукты;
  • яйца;
  • морская рыба;
  • печень;
  • злаки;
  • свежая зелень;
  • соя.

Чтобы усвоение веществ проходило нормально, не следует ограничивать употребление жиров. Поэтому не нужно чрезмерно увлекаться диетами, если заботитесь о своем здоровье. Высокое содержание соли в пище приводит к тому, что кальций выводится из костей, выходит из организма с мочой, поэтому следует ограничить этот продукт.

Когда организму не хватает кальция, поступающего с пищей, следует прибегнуть к фармацевтическим препаратам. Они стимулируют образование костных клеток. Эти лекарства могут в редких случаях спровоцировать аллергическую реакцию, а их передозировка вызывает гиперкальцитонический криз. И хотя в практике такое состояние не наблюдалось, забывать о риске не стоит.

Quodixor

Кому она важна

QuodixorМеры по предотвращению остеопороза более всего важны для женщин и пожилых людей.

Важно заниматься профилактикой остеопороза с детского возраста, именно в этот период кости укрепляются, и формируется их структура. Полноценное питание является профилактикой разрушения костей

Отказ от употребления алкоголя и курения — это тоже действенная мера против ослабления скелета.

По статистике, именно женщины чаще всего болеют остеопорозом, особенно дамы с хрупким телосложением, поэтому профилактика такого заболевания для женщин является обязательной. Также подвержены заболеванию люди, которые пережили голодное детство. Женщины, чьи родители имели остеопороз или рано вступившие в период менопаузы — гормональные изменения ухудшают обменные процессы и усвояемость кальция.

В пожилом возрасте профилактика остеопороза нацелена на то, чтобы снизить риск возникновения переломов, так как со временем организм теряет способность усваивать кальций в нужном объеме. Для достижения положительного эффекта принимают такие меры:

  • коррекция массы тела;
  • исключение вредных привычек;
  • употребление витамина Д и кальция;
  • здоровый и активный образ жизни.

Reviews

User reports

Consumer reported frequency of use

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1 consumer reported doses

What doses of Quodixor drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Quodixor drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.

Users

%

101-200mg 1 100.0%

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Information checked by Dr. Sachin Kumar, MD Pharmacology

rodki ostronoci

Przed rozpoczęciem leczenia należy koniecznie wyrównać istniejącą hipokalcemię oraz inne zaburzenia metabolizmu kostnego i mineralnego. Pacjenci powinni otrzymywać suplementy wapnia i (lub) witaminę D, jeśli ich zawartość w diecie jest niewystarczająca. Z powodu możliwego działania drażniącego i potencjalnego pogorszenia choroby podstawowej, należy zachować ostrożność u pacjentów z czynną chorobą górnego odcinka przewodu pokarmowego (np. przełyk Barreta, dysfagia, inne choroby przełyku, zapalenie błony śluzowej żołądka, dwunastnicy lub owrzodzenie). Lekarze powinni zwracać szczególną uwagę na jakiekolwiek objawy mogące świadczyć o możliwości reakcji ze strony przełyku i poinstruować pacjentów, by przerwali stosowanie kwasu ibandronowego i zgłosili się w celu uzyskania pomocy medycznej, jeśli rozwinie się u nich dysfagia, bolesne połykanie, ból zamostkowy lub wystąpi zgaga lub jej nasilenie. Ze względu na ryzyko podrażnienia przewodu pokarmowego należy zachować ostrożność podczas jednoczesnego stosowania preparatu i NLPZ. Nie zaleca się stosowania kwasu ibandronowego u pacjentów z klirensem kreatyniny

Uses of Quodixor in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Quodixor is used to treat and prevent bones from becoming weak and brittle (osteoporosis) in menopausal women. It is also used to treat high calcium levels in the blood due to secondary bone cancer and metastasis of bone due to breast cancer.

Dawkowanie

Doustnie. Dorośli: zalecana dawka to 1 tabl. powl. 150 mg raz na miesiąc. Tabletkę należy przyjmować tego samego dnia każdego miesiąca. Preparat należy przyjmować po całonocnym okresie niejedzenia (co najmniej 6 h od ostatniego posiłku), na 1 h przed pierwszym posiłkiem lub napojem (innym niż woda) w danym dniu lub jakimkolwiek innym doustnym lekiem lub innym suplementem (włączając wapń). W przypadku pominięcia dawki, pacjentów należy poinstruować, żeby przyjęli 1 tabl. preparatu następnego dnia rano po dniu, w którym pacjent przypomni sobie o pominiętej dawce, jeśli do następnej zaplanowanej dawki zgodnie ze schematem zostało więcej niż 7 dni. Następnie pacjenci powinni wrócić do przyjmowania preparatu raz na miesiąc zgodnie z dotychczasowym schematem dawkowania. Jeśli do następnej zaplanowanej dawki zostało mniej niż 7 dni, pacjenci powinni zaczekać do tej najbliższej dawki i kontynuować przyjmowanie 1 tabl. raz na miesiąc zgodnie z dotychczasowym schematem. Pacjenci nie powinni przyjmować 2 tabl. w tym samym tygodniu. U pacjentów z łagodnymi i umiarkowanymi zaburzeniami czynności nerek (klirens kreatyniny ≥30 ml/min), zaburzeniami czynności wątroby oraz u pacjentów w podeszłym wieku nie jest konieczne dostosowywanie dawki. Tabletki należy połykać w całości popijając szklanką zwykłej wody (180-240 ml), w pozycji wyprostowanej (siedzącej lub stojącej). Po przyjęciu preparatu nie należy przyjmować pozycji leżącej przez 1 h. Zwykła woda jest jedynym napojem, którym należy popić preparat. Należy pamiętać, że niektóre wody mineralne mogą zawierać większe stężenie wapnia i z tego względu nie należy ich stosować. Nie należy żuć ani ssać tabletek, ponieważ lek może powodować owrzodzenia błony śluzowej jamy ustnej i gardła.

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One patient reported frequency of use

How often should I take Quodixor?According to the survey, gMedication.com reported that users of Quodixor should take Once in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here.

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Once in a day 1 100.0%

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One patient reported doses

What is the specific doses you have used?Quodixor May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient’s condition. According to our reports, users of gMedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.

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%

101-200mg 1 100.0%

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One patient reported age

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> 60 1 100.0%

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The information was verified by Dr. Harshad Shah, MD Pharmacology

Dziaanie

Lek z grupy bisfosfonianów o wybiórczym działaniu na tkankę kostną. Hamuje aktywność osteoklastów bez wywierania bezpośredniego wpływu na proces syntezy kostnej. Nie wpływa również na mobilizację osteoklastów. U kobiet po menopauzie lek powoduje wzmocnienie struktury masy kostnej i zmniejszenie częstości złamań, dzięki zwolnieniu przyspieszonego obrotu metabolicznego kości do poziomu sprzed menopauzy. Wchłanianie kwasu ibandronowego w górnym odcinku przewodu pokarmowego po podaniu doustnym jest szybkie. Maksymalne stężenia w osoczu osiągane są w ciągu 0,5-2 h u pacjentów na czczo, a całkowita biodostępność wynosi ok. 0,6%. Wchłanianie jest zmniejszone w przypadku, gdy preparat podawany jest razem z posiłkami lub napojami (innymi niż zwykła woda). Biodostępność jest zmniejszona o ok. 90%, jeśli kwas ibandronowy przyjmowany jest ze standardowym śniadaniem w porównaniu z biodostępnością obserwowaną u pacjentów na czczo. Nie obserwuje się znaczącego zmniejszenia w biodostępności, jeśli kwas ibandronowy przyjmowany jest na 60 min przed posiłkiem. Po pierwszym podaniu ogólnoustrojowym, kwas ibandronowy ulega szybkiemu wiązaniu przez kości lub jest wydalany z moczem. Odsetek krążącej dawki, który dociera do tkanki kostnej szacowany jest na 40-50%. Wiązanie z białkami osocza wynosi 85-87%. Brak dowodów na to, że kwas ibandronowy jest metabolizowany. Kwas ibandronowy, który nie został wchłonięty, jest wydalany w stanie niezmienionym z kałem. Pozorny końcowy T0,5 mieści się w przedziale 10-72 h.

Quodixor interactions

See also:What other drugs will affect Quodixor?

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Drug-Food Interactions: Products containing calcium and other multivalent cations (eg, aluminium, magnesium, iron), including milk and food, are likely to interfere with absorption of Quodixor which is consistent with findings in animal studies. Therefore, with such products, including food, intake must be delayed for 60 min following oral administration.

Drug-Drug Interactions: It is likely that calcium supplements, antacids and some oral medications containing multivalent cations (eg, aluminium, magnesium, iron) are likely to interfere with the absorption of Quodixor. Therefore, patients must wait 60 min after taking Quodixor before taking other oral medications.

Pharmacokinetic interaction studies in postmenopausal women have demonstrated the absence of any interaction potential with tamoxifen or hormone replacement therapy (estrogen). No interaction was observed when co-administered with melphalan/prednisolone in patients with multiple myeloma.

In healthy male volunteers and postmenopausal women, IV ranitidine caused an increase in Quodixor bioavailability of about 20%, probably as a result of reduced gastric acidity. However, since this increase is within the normal range of the bioavailability of Quodixor, no dosage adjustment is required when Quodixor is administered with H2-antagonists or other drugs which increase gastric pH.

In relation to disposition, no drug interactions of clinical significance are considered likely, since Quodixor does not inhibit the major human hepatic P450 isoenzymes and has been shown not to induce the hepatic cytochrome P450 system in rats. Furthermore, plasma protein binding is low at therapeutic concentrations and Quodixor is therefore unlikely to displace other drugs.

Quodixor is eliminated by renal excretion only and does not undergo any biotransformation. The secretory pathway appears not to include known acidic or basic transport systems involved in the excretion of other drugs.

In a 1-year study in postmenopausal women with osteoporosis (BM16549), the incidence of upper gastrointestinal events in patients concomitantly taking aspirin or NSAIDs was similar in patients taking Quodixor 2.5 mg daily or 150 mg once monthly.

Of over 1500 patients enrolled in study BM16549 comparing monthly with daily dosing regimens of Quodixor, 14% of patients used histamine (H2)-blockers or proton-pump inhibitors. Among these patients, the incidence of upper gastrointestinal events in the patients treated with Quodixor 150 mg once monthly was similar to that in patients treated with Quodixor 2.5 mg daily.

Вывод

Остеопороз – коварное заболевание, о котором пациент часто даже не подозревает. Полностью вылечить его не представляется возможным, но замедлить или вовсе остановить процессы разрушения костей можно. Для этого нужно принимать комплекс препаратов, который подберет врач. Самолечение этого заболевания допускать нельзя, так как во многих случаях требуется гормональная терапия.

Для предотвращения заболевания часто используются соли кальция, назначают прием витамина Д, для женщин пожилого возраста используют эстрогены, и модуляторы эстрогеновых рецепторов. Лечение заболевания, которое уже развилось, происходит с помощью витамина Д, Бивалоса, андрогенов, кальцитонина и иных веществ

Данное разделение лекарственных средств условное, врач делает назначение при обследовании пациента, поэтому важно не лечить заболевание самостоятельно, а обращаться к доктору.

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